Caleva Blog

Caleva Mini Coater Drier Helps to Reintroduce Endangered Native Australian Animals

Many experts recognise Caleva as a leading manufacturer in extrusion and spheronization equipment for the development of pharmaceutical formulations, catalysts and ceramics. However, the broard scope and flexibility of Caleva equipment provides diverse capabilities that is leading to emerging applications in implant manufacture and conservation science. To explain more, we caught up with Dr...

Does the Caleva Mixer/Granulator/Blender allow me to mix and test small batches of product?

We are frequently asked for information about the ability of the small mixer/granulator/blender, a must have tool for any laboratory needing to complete these processes quickly with small sample sizes. Recent trials provide new information about the the capability of the Caleva mixer/granulator/blender (MGB) and its ability to act as a stand alone mixer when mixing powder samples of different...

Mini Coater Drier support at Dai Nam University Vietnam

Mini Coater Drier support at Dai Nam University VietnamHỗ trợ kỹ thuật tại đại học Đại NamThe exclusive Caleva representative in Vietnam (ATI)* recently installed a Caleva Mini Coater Drier (Caleva MCD) in Dai Nam University Pharmaceutical Department (Hanoi – Vietnam). Dr Steve Robinson (Caleva) and with Mr Hung Nguyen (from ATI) recently made a follow-up visit following the installation some...

How can I be sure that the trials and development work that I do will give me comparable results when I need to scale up to production sizes?

Scale up of the spheronization process is relatively well known and understood. All of the Caleva extrusion and spheronization equipment is designed with scale up in mind.Our range of screw extruders from have the ability to modify the density of your extrudate when this is important.
  • The smallest Caleva Multi Lab (CML) with an extruder attachment designed to work with batches as little of 20...

New installation at Tupras oil refinery in Turkey

 

Meet Caleva at CPHI Madrid

 

Effect of spheronizer plate design on the spheronization of ketoprofen

Abstract: Spheronization is a rapid process for production of microspheres. The process involves the dry mixing of drug with microcrystalline cellulose (MCC), which on subsequent wetting with water forms a plastic mass suitable for extrusion and spheronization. As in any pharmaceutical operation, large number of factors may affect the production of pellets, which can be related to formulation...

Extrusion–spheronization a promising pelletization technique: In-depth review

Abstract

This review article deals with various aspects of the extrusion–spheronization technique. The first part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. In the second part, the parameters which can influence the quality of pellets including formulation (moisture content, granulating liquid, excipients, and...

Spheronized Pellets for Extended Release of Poorly Soluble Antiemetic Agent

Thanks to Caleva not only for making great equipment but also for being helpful to give us access to it within our budget. I would ALSO like to thank Caleva for the help given in providing the small scale extrusion and spheronization equipment for our laboratory. The latest research paper from our pharmaceutical department (Lipids bearing extruded-spheronized pellets for extended release of...

How reproducible can measurements be of something that is not homogeneous?

The MTR-3 uniquely offers a means of characterising the rheological properties of a wet granulation by providing a quantitative value of the consistency of the material tested. The more traditional hand squeeze test, previously widely used, to measure or compare granulations, is falling into disrepute and is no longer considered appropriate for modern day industrial production or research...