Caleva Blog

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Effect of spheronizer plate design on the spheronization of ketoprofen

Abstract: Spheronization is a rapid process for production of microspheres. The process involves the dry mixing of drug with microcrystalline cellulose (MCC), which on subsequent wetting with water forms a plastic mass suitable for extrusion and spheronization. As in any pharmaceutical operation, large number of factors may affect the production of pellets, which can be related to formulation...

Extrusion–spheronization a promising pelletization technique: In-depth review

Abstract

This review article deals with various aspects of the extrusion–spheronization technique. The first part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. In the second part, the parameters which can influence the quality of pellets including formulation (moisture content, granulating liquid, excipients, and...

Spheronized Pellets for Extended Release of Poorly Soluble Antiemetic Agent

Thanks to Caleva not only for making great equipment but also for being helpful to give us access to it within our budget. I would ALSO like to thank Caleva for the help given in providing the small scale extrusion and spheronization equipment for our laboratory. The latest research paper from our pharmaceutical department (Lipids bearing extruded-spheronized pellets for extended release of...

How reproducible can measurements be of something that is not homogeneous?

The MTR-3 uniquely offers a means of characterising the rheological properties of a wet granulation by providing a quantitative value of the consistency of the material tested. The more traditional hand squeeze test, previously widely used, to measure or compare granulations, is falling into disrepute and is no longer considered appropriate for modern day industrial production or research...

Yield problems in production and quality control

 One of the strengths of the Caleva Mixer Torque Rheometer (MTR-3) is that it can be used to verify the properties of wet powder masses of samples taken during production in large scale mixer/granulator systems. It can be used simply as a QC tool on a regular basis or specifically as an aid to problem solving. Small samples can be taken directly from production and within two minutes a...

I have inconsistent extrusion & spheronization results with a difficult active ingredient?

The following case study demonstrates how the Caleva Mixer Torque Rheometer.  The MTR-3 was an invaluable aid in a specific case. A manufacturer of generic Venlafaxine pellets was experiencing inconsistent results from their manufacturing line. The resultant product was variable in both usable yield (weight of acceptable pellets as a % of weight of granulation made), and dissolution profile....

How the Mixer Torque Rheometer resolved a tablet friability issue

Caleva worked closely with a well known producer of food supplements made from natural materials, plant extracts and other natural food sources.  Their tablet formulations work well and this nutraceutical company has a good reputation for their products.  Generally they do not encounter problems with tablets breaking or disintegrating during manufacture, packing or storage.

Determination of moisture requirement to prepare spheroids by extrusion-spheronization

Spheroids are popularly used in the design of multi-particulate drug delivery systems. Extrusion and spheronization is commonly employed to manufacture spheroids in the pharmaceutical industry. It is a multiple-step manufacturing process which could be summarized into the flow chart as shown in Figure 1.

Save Time and Cost in Formulation Development

In the mid 1990’s, the field of pyrotechnics was limited mainly to applications in aircraft ordnance, fireworks and rock blasting. This has been developed to a highly advanced science and is an extensively used technology which finds application in spacecraft, aircraft and underwater vehicle systems. “Pyrotechnic “is defined as “explosive-actuated” and refers especially to devices in which...