Caleva Blog

Can power use in granulation predict tablet dissolution & hardness?

The recent research paper from Tomoto Otsuka et al (Chem. Pharm. Bull. 66, 554-561 2018) have shown that high shear granulation processes can influence final product properties such as tablet dissolution and hardness.The question raised by this paper was related to useful methods of evaluating the “kneading state” of a wet mass obtained during the granulation process. The most commonly used...

Agglomeration properties of gluten-free flours under water addition and shearing conditions

The different states of agglomeration were identified by the evolution of rheological properties under water addition and shearing conditions using a Caleva® mixer torque rheometer. 

New installation at Tupras oil refinery in Turkey

 

How reproducible can measurements be of something that is not homogeneous?

The MTR-3 uniquely offers a means of characterising the rheological properties of a wet granulation by providing a quantitative value of the consistency of the material tested. The more traditional hand squeeze test, previously widely used, to measure or compare granulations, is falling into disrepute and is no longer considered appropriate for modern day industrial production or research...

Yield problems in production and quality control

 One of the strengths of the Caleva Mixer Torque Rheometer (MTR-3) is that it can be used to verify the properties of wet powder masses of samples taken during production in large scale mixer/granulator systems. It can be used simply as a QC tool on a regular basis or specifically as an aid to problem solving. Small samples can be taken directly from production and within two minutes a...

I have inconsistent extrusion & spheronization results with a difficult active ingredient?

The following case study demonstrates how the Caleva Mixer Torque Rheometer.  The MTR-3 was an invaluable aid in a specific case. A manufacturer of generic Venlafaxine pellets was experiencing inconsistent results from their manufacturing line. The resultant product was variable in both usable yield (weight of acceptable pellets as a % of weight of granulation made), and dissolution profile....

How the Mixer Torque Rheometer resolved a tablet friability issue

Caleva worked closely with a well known producer of food supplements made from natural materials, plant extracts and other natural food sources.  Their tablet formulations work well and this nutraceutical company has a good reputation for their products.  Generally they do not encounter problems with tablets breaking or disintegrating during manufacture, packing or storage.

Determination of moisture requirement to prepare spheroids by extrusion-spheronization

Spheroids are popularly used in the design of multi-particulate drug delivery systems. Extrusion and spheronization is commonly employed to manufacture spheroids in the pharmaceutical industry. It is a multiple-step manufacturing process which could be summarized into the flow chart as shown in Figure 1.

Save Time and Cost in Formulation Development

In the mid 1990’s, the field of pyrotechnics was limited mainly to applications in aircraft ordnance, fireworks and rock blasting. This has been developed to a highly advanced science and is an extensively used technology which finds application in spacecraft, aircraft and underwater vehicle systems. “Pyrotechnic “is defined as “explosive-actuated” and refers especially to devices in which...

"End Point Determination” Using the Caleva Mixer Torque Rheometer

A company wished to move a formulation currently undergoing product development from small scale laboratory (with batches of 50 grams) to the next stage for a larger scale batch trial of 100 kg (scale–up).  The development had been started using a small Caleva Multi Lab bench top mixer (maximum batch capacity 50 gram of wet mass). This development had been successful and now additional samples...

Practical Approach on Industrial Rheology and Rheometry - MCIK Annual Seminar

Join Caleva's partner MCIK for their annual seminar

Major European Chemistry & Catalysis Department uses Caleva Multi Lab in new catalyst formulations to gain greater thermal stability

Why is platinum and palladium in automotive catalyst formulations?

Pharmacy Students from University of Reading visit Caleva’s Laboratory

We were delighted to welcome Akhil and Mohammed to our laboratory in the UK for training on our laboratory equipment. They both worked with the Mini Coater Drier and Mixer Torque Rheometer as well as the Caleva Multi Lab. It was an enjoyable day for all and we appreciate their visit and they are welcome to visit us again in the future. Indeed, if any pharmacy student would like to come and...

Pharmaceutical Technology Group purchase a Caleva Mixer Torque Rheometer (MTR3)

PharmaTeG – Pharmaceutical Technology Group - is founded by a group of pharmaceutical technologists belonging to the Department of Pharmaceutical and Pharmacological Science and School of Hospital Pharmacy, University of Padova, Italy. The group collaborates with the Industrial Engineering Department of the University of Padova (APTLab – Advanced Particle Technology Laboratory) with whom it...

Caleva Mixer Torque Rheometer - The importance of mixing time for your formulation development and production

It is well established and understood that one of the most important factors in the development of a formulation for both tableting and making pellets by extrusion and spheronization is the amount of liquid binder added to the formulation. What is less widely acknowledged is the importance of mixing and the mixing regime used. The concept of “granulation end point” is recognised but there is...

Caleva Visit to GPO in Thailand on 27th March 2013

he Thai GPO (Government Pharmaceutical Organisation) based in Bangkok has been a user of Caleva bench-top extruders and spheronizers as well as the Caleva Mixer Torque Rheometer for many years.   A meeting was held to discuss on-going work to see if any of the formulations developed in the laboratory are now ready for progression to pilot scale or production.  Caleva have supplied equipment...