Caleva Blog

Effect of spheronizer plate design on the spheronization of ketoprofen

Abstract: Spheronization is a rapid process for production of microspheres. The process involves the dry mixing of drug with microcrystalline cellulose (MCC), which on subsequent wetting with water forms a plastic mass suitable for extrusion and spheronization. As in any pharmaceutical operation, large number of factors may affect the production of pellets, which can be related to formulation...

Extrusion–spheronization a promising pelletization technique: In-depth review

Abstract

This review article deals with various aspects of the extrusion–spheronization technique. The first part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. In the second part, the parameters which can influence the quality of pellets including formulation (moisture content, granulating liquid, excipients, and...

Spheronized Pellets for Extended Release of Poorly Soluble Antiemetic Agent

Thanks to Caleva not only for making great equipment but also for being helpful to give us access to it within our budget. I would ALSO like to thank Caleva for the help given in providing the small scale extrusion and spheronization equipment for our laboratory. The latest research paper from our pharmaceutical department (Lipids bearing extruded-spheronized pellets for extended release of...

Systematic investigation of the shape evaluation results of solid lipid pellets with diverse composition employing two different characterization methods

Systematic investigation of the shape evaluation results of solid lipid pellets with diverse composition employing two different characterization methods

Carnauba wax as a promising excipient in melt granulation targeting the preparation of mini-tablets for sustained release of highly soluble drugs

Carnauba wax as a promising excipient in melt granulation targeting the preparation of mini-tablets for sustained release of highly soluble drugsV Nart, AOR Beringhs, MT França, B de Espíndola… - Materials Science and …, 2016... M1) were coated using different polymeric dispersions and weight gains, resulting in four coated formulations, named M1-A, M1-B, M1-C and M1-D (Table 3). The coating...

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