Caleva Blog

Can power use in granulation predict tablet dissolution & hardness?

The recent research paper from Tomoto Otsuka et al (Chem. Pharm. Bull. 66, 554-561 2018) have shown that high shear granulation processes can influence final product properties such as tablet dissolution and hardness.The question raised by this paper was related to useful methods of evaluating the “kneading state” of a wet mass obtained during the granulation process. The most commonly used...