Caleva Blog

Effect of spheronizer plate design on the spheronization of ketoprofen

Abstract: Spheronization is a rapid process for production of microspheres. The process involves the dry mixing of drug with microcrystalline cellulose (MCC), which on subsequent wetting with water forms a plastic mass suitable for extrusion and spheronization. As in any pharmaceutical operation, large number of factors may affect the production of pellets, which can be related to formulation...

Yield problems in production and quality control

 One of the strengths of the Caleva Mixer Torque Rheometer (MTR-3) is that it can be used to verify the properties of wet powder masses of samples taken during production in large scale mixer/granulator systems. It can be used simply as a QC tool on a regular basis or specifically as an aid to problem solving. Small samples can be taken directly from production and within two minutes a...